Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Melanocyte
DISEASE(S): Melanoma
SUBMITTER: Pavel Shliaha
LAB HEAD: Ronald Hendrickson
PROVIDER: PXD027968 | Pride | 2022-01-12
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
PD.zip | Other | |||
human_2019_06_14_uniprot_rev_can.fasta | Fasta | |||
white_IP3_.pep.xml | Pepxml | |||
white_IP3_01.raw | Raw | |||
white_IP3_02.raw | Raw |
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Nature 20220330 7905
Oncogenic alterations to DNA are not transforming in all cellular contexts<sup>1,2</sup>. This may be due to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic position as a major determinant of why cells respond to specific oncogenes. Cutaneous melanoma arises throughout the body, whereas the acral subtype arises on the palms of the hands, soles of the feet or under the nails<sup>3</sup>. We sequenced the DNA of cutaneous and acral melanomas from a large coho ...[more]