Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Heart
SUBMITTER: Mikel Azkargorta
LAB HEAD: Felix Elortza
PROVIDER: PXD027974 | Pride | 2022-05-20
REPOSITORIES: Pride
Items per page: 1 - 5 of 14 |
Scientific reports 20220427 1
2-Deoxy-D-glucose (2DG) has recently received emergency approval for the treatment of COVID-19 in India, after a successful clinical trial. SARS-CoV-2 infection of cultured cells is accompanied by elevated glycolysis and decreased mitochondrial function, whereas 2DG represses glycolysis and stimulates respiration, and restricts viral replication. While 2DG has pleiotropic effects on cell metabolism in cultured cells it is not known which of these manifests in vivo. On the other hand, it is known ...[more]