Proteomics

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Proteomic analysis of mouse hearts treated with and without 2-deoxy-D-glucose

ABSTRACT: 2-deoxy-D-glucose (2DG) is a glucose analog that is established to inhibit glucose metabolism via glycolysis. It has long been recognized as a potential chemical mimetic of calorie restriction, and it also has been shown to have anti-viral effects in infected cells, against among others SARS-CoV-2. This study aimed to determine whether intermittent treatment of mice with 2DG could alter nutrient metabolism in vivo and whether this would produce a proteomic signature of altered glucose metabolism and other cellular pathways, with a view to explaining the anti-viral properties of 2DG. Parallel physiological studies of the heart aimed to relate any proteomic changes to the function and performance of the heart, including assessing whether there were any signs of detrimental effects of 2DG.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Mikel Azkargorta  

LAB HEAD: Felix Elortza

PROVIDER: PXD027974 | Pride | 2022-05-20

REPOSITORIES: Pride

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Dataset's files

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Action DRS
210311_210211B_Irati_Holdt_10_S1-B10_1_1046.d.7z Other
210311_210211B_Irati_Holdt_11_S1-B11_1_1047.d.7z Other
210311_210211B_Irati_Holdt_12_S1-B12_1_1048.d.7z Other
210311_210211B_Irati_Holdt_1_S1-B1_1_1037.d.7z Other
210311_210211B_Irati_Holdt_2_S1-B2_1_1038.d.7z Other
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Publications

2-Deoxy-D-glucose (2DG) has recently received emergency approval for the treatment of COVID-19 in India, after a successful clinical trial. SARS-CoV-2 infection of cultured cells is accompanied by elevated glycolysis and decreased mitochondrial function, whereas 2DG represses glycolysis and stimulates respiration, and restricts viral replication. While 2DG has pleiotropic effects on cell metabolism in cultured cells it is not known which of these manifests in vivo. On the other hand, it is known  ...[more]

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