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Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density

ABSTRACT: The RNA binding protein LIN28A is a stem- and progenitor marker and one of the factors necessary to induce pluripotent stem cells in vitro. LIN28A has been shown to promote the proliferative capacity of neural progenitor cells but its specific role during embryonal and postnatal brain development still remains widely unknown. A high and characteristic overexpression of LIN28A has been identified in malignant brain tumors called embryonal tumors with multilayered rosettes (ETMR). Radial glia cells of the ventricular zone are proposed as a cell of origin for those tumors.

INSTRUMENT(S): Orbitrap Fusion, Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Christoph Krisp

LAB HEAD: Julia Neumann

PROVIDER: PXD028044 | Pride | 2022-02-15

REPOSITORIES: Pride

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Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density.

Middelkamp Maximilian M Ruck Lisa L Krisp Christoph C Sumisławski Piotr P Mohammadi Behnam B Dottermusch Matthias M Meister Valerie V Küster Lukas L Schlüter Hartmut H Windhorst Sabine S Neumann Julia E JE

Acta neuropathologica communications 20211120 1

LIN28A overexpression has been identified in malignant brain tumors called embryonal tumors with multilayered rosettes (ETMR) but its specific role during brain development remains largely unknown. Radial glia cells of the ventricular zone (VZ) are proposed as a cell of origin for ETMR. We asked whether an overexpression of LIN28A in such cells might affect brain development or result in the formation of brain tumors.Constitutive overexpression of LIN28A in hGFAP-cre::lsl-Lin28A (GL) mice led to ...[more]

PMID: 34801069

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	190311_CK_MM_1052B.mzML	Mzml
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	190311_CK_MM_1052E.mzML	Mzml