Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cerebrospinal Fluid, Primary Neuron
SUBMITTER: Stephan Mueller
LAB HEAD: Stefan F. Lichtenthaler
PROVIDER: PXD028096 | Pride | 2021-10-07
REPOSITORIES: Pride
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20200622_114518_iSPECS_neuron_iR1KO_DIA_Mouseo_...__.sne.zip | Other | |||
JT_002_CSF_07.raw | Raw | |||
JT_002_CSF_45.raw | Raw | |||
JT_002_CSF_46.raw | Raw | |||
JT_002_CSF_48.raw | Raw |
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20211101 11
Proteolytic ectodomain shedding of membrane proteins is a fundamental mechanism to control the communication between cells and their environment. A key protease for membrane protein shedding is ADAM17, which requires a non-proteolytic subunit, either inactive Rhomboid 1 (iRhom1) or iRhom2 for its activity. While iRhom1 and iRhom2 are co-expressed in most tissues and appear to have largely redundant functions, the brain is an organ with predominant expression of iRhom1. Yet, little is known about ...[more]