Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Breast, Breast Cancer Cell Line
DISEASE(S): Breast Cancer
SUBMITTER: Elena Panizza
LAB HEAD: Richard A. Cerione
PROVIDER: PXD028114 | Pride | 2023-03-10
REPOSITORIES: Pride
Action | DRS | |||
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Arash10400399_Band1_60kD-_2_.msf | Msf | |||
Arash10400399_Band1_60kD-_2_.pdResult | Other | |||
Arash10400399_Band1_60kD.raw | Raw | |||
Arash10400399_Band1_60kD.xlsx | Xlsx | |||
Arash10400399_Band2_85kD-_1_.msf | Msf |
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Proceedings of the National Academy of Sciences of the United States of America 20221102 45
IGF2BP2 binds to a number of RNA transcripts and has been suggested to function as a tumor promoter, although little is known regarding the mechanisms that regulate its roles in RNA metabolism. Here we demonstrate that IGF2BP2 binds to the 3' untranslated region of the transcript encoding ATP6V1A, a catalytic subunit of the vacuolar ATPase (v-ATPase), and serves as a substrate for the NAD<sup>+</sup>-dependent deacetylase SIRT1, which regulates how IGF2BP2 affects the stability of the ATP6V1A tr ...[more]