Dataset Information

Protein Signatures to Distinguish Aggressive from Indolent Prostate Cancer

ABSTRACT: We performed a mass spectrometry-based proteomic analysis of normal and malignant prostate tissues from 22 men who underwent surgery for prostate cancer. Prostate cancer samples included Grade Groups (3 to 5), with 8 patients experiencing recurrence and 14 without evidence of recurrence with a mean of 6.8 years of follow-up.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Prostate Gland

DISEASE(S): Prostate Cancer

SUBMITTER: Sharon Pitteri

LAB HEAD: Sharon Pitteri

PROVIDER: PXD028118 | Pride | 2022-05-04

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Key.xlsx	Xlsx
	P10A_092518_01.raw	Raw
	P10A_092518_01.raw_20181017_Byonic_database.xlsx	Xlsx
	P10A_092518_02.raw	Raw
	P10A_092518_02.raw_20181017_Byonic_database.xlsx	Xlsx

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Publications

Protein signatures to distinguish aggressive from indolent prostate cancer.

Garcia-Marques Fernando F Liu Shiqin S Totten Sarah M SM Bermudez Abel A Tanimoto Cheylene C Hsu En-Chi EC Nolley Rosalie R Hembree Amy A Stoyanova Tanya T Brooks James D JD Pitteri Sharon J SJ

The Prostate 20220131 5

<h4>Background</h4>Distinguishing men with aggressive from indolent prostate cancer is critical to decisions in the management of clinically localized prostate cancer. Molecular signatures of aggressive disease could help men overcome this major clinical challenge by reducing unnecessary treatment and allowing more appropriate treatment of aggressive disease.<h4>Methods</h4>We performed a mass spectrometry-based proteomic analysis of normal and malignant prostate tissues from 22 men who underwen ...[more]

PMID: 35098564

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