Dataset Information

Detection of Circulating Serum Protein Biomarkers of Non-muscle Invasive Bladder Cancer after the Protein Corona-Silver Nanoparticles Analysis by SWATH-MS

ABSTRACT: Because cystoscopy is expensive and invasive, a new method of detecting non-invasive muscular bladder cancer (NMIBC) is needed. This study aims to identify potential serum protein markers for NMIBC to improve diagnosis and to found treatment approaches to avoid disease progression to a life-threatening phenotype (muscle-invasive bladder cancer, MIBC). Here, silver nanoparticles (AgNPs, 9.73 ± 1.70 nm) as a scavenging device together with Sequential Window Acquisition of All Theoretical Mass Spectra (SWATH-MS) were used to quantitative analyze the blood serum protein al-terations in two NMIBC subtypes: T1 and Ta, and they were compared to normal samples (HC). NMIBC's analysis of serum samples identified three major groups of proteins, the relative content of which is different from the HC content: proteins implicated in the complement and coagulation cascade pathways and apolipoproteins. In conclusion, many biomarker proteins were identified that merit further examination to validate their useful significance and utility within the clinical management of NMIBC patients.

INSTRUMENT(S): TripleTOF 6600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Breast Cancer

SUBMITTER: Susana Bravo

LAB HEAD: Susana Bravo

PROVIDER: PXD028310 | Pride | 2022-02-15

REPOSITORIES: Pride

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Detection of Circulating Serum Protein Biomarkers of Non-Muscle Invasive Bladder Cancer after Protein Corona-Silver Nanoparticles Analysis by SWATH-MS.

Gómez Benito Blanco BB López-Cortés Rubén R Casas-Nebra Francisco Javier FJ Vázquez-Estévez Sergio S Pérez-Fentes Daniel D Chantada-Vázquez María Del Pilar MDP Bravo Susana B SB Núñez Cristina C

Nanomaterials (Basel, Switzerland) 20210913 9

Because cystoscopy is expensive and invasive, a new method of detecting non-invasive muscular bladder cancer (NMIBC) is needed. This study aims to identify potential serum protein markers for NMIBC to improve diagnosis and to find treatment approaches that avoid disease progression to a life-threatening phenotype (muscle-invasive bladder cancer, MIBC). Here, silver nanoparticles (AgNPs, 9.73 ± 1.70 nm) as a scavenging device together with sequential window acquisition of all theoretical mass spe ...[more]

PMID: 34578700

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			Action	DRS
	30ppm__Ta_to_T1_.xls	Xls
	PCVJ10_R1.wiff	Wiff
	PCVJ10_R1.wiff.scan	Wiff
	PCVJ10_R2.wiff	Wiff
	PCVJ10_R2.wiff.scan	Wiff