Dataset Information

Serum amyloid A correlates with the osteonecrosis of femoral head

ABSTRACT: We observed 21 prominent protein spots that differed between the two groups. Three of these proteins were upregulated and the rest 18 proteins were downregulated in patients with steroid-induced ONFH. The spots determined in the steroid-induced ONFH and health control groups were replicable.The spot no. 21 corresponding to an upregulated protein in patients with steroid-induced ONFH was identified as SAA.

INSTRUMENT(S): 4700 Proteomics Analyzer

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

SUBMITTER: Xiaoyuan Peng

LAB HEAD: Yong Feng

PROVIDER: PXD028318 | Pride | 2022-02-15

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20110629-jibing-3-10-100ug-46768-sil.tif	Other
	20110629-jibing-3-10-100ug-46770-sil.tif	Other
	20110629-zhengchang-3-10-100ug-46136-sil.tif	Other
	20110629-zhengchang-3-10-100ug-46771-sil.tif	Other
	20110629-zhengchang-3-10-100ug-46772-sil.tif	Other

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Publications

Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism.

Peng Xiaoyuan X Ma Yiyang Y Wang Qiyang Q Gao Yanchun Y Li Guangyi G Jiang Chenyi C Gao Yun Y Feng Yong Y

Frontiers in pharmacology 20211018

Osteonecrosis of femoral head (ONFH) is a progressive hip joint disease without disease-modifying treatment. Lacking understanding of the pathophysiological process of ONFH has become the humper to develop therapeutic approach. Serum amyloid A (SAA) is an acute phase lipophilic protein during inflammation and we found that SAA is increased for the first time in the serum of ONFH patients through proteomic studies and quantitatively verified by ELISA. Treating rBMSCs with SAA inhibited the osteog ...[more]

PMID: 34733165

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