Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Gut, Extracellular Vesicle
DISEASE(S): Type 2 Diabetes Mellitus
SUBMITTER: Rune Matthiesen
LAB HEAD: Rune Matthiesen
PROVIDER: PXD028338 | Pride | 2022-04-04
REPOSITORIES: Pride
Ferreira Inês I Machado de Oliveira Rita R Carvalho Ana Sofia AS Teshima Akiko A Beck Hans Christian HC Matthiesen Rune R Costa-Silva Bruno B Macedo Maria Paula MP
Journal of proteome research 20220309 4
Extracellular vesicles (EVs) mediate communication in physiological and pathological conditions. In the pathogenesis of type 2 diabetes, inter-organ communication plays an important role in its progress and metabolic surgery leads to its remission. Moreover, gut dysbiosis is emerging as a diabetogenic factor. However, it remains unclear how the gut senses metabolic alterations and whether this is transmitted to other tissues via EVs. Using a diet-induced prediabetic mouse model, we observed that ...[more]