Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Bone Marrow
SUBMITTER: Midy Wu
LAB HEAD: Sidonia Fagarasan
PROVIDER: PXD028403 | Pride | 2021-11-15
REPOSITORIES: Pride
Items per page: 1 - 5 of 16 |
Nature 20211103 7885
Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu<sup>1-3</sup>. Here we identify the metabolite and neurotransmitter GABA as a candidate signalling molecule synthesized and secreted by activated B cells and plasma cells. We show that B cell-derived GABA promotes monocyte differentiation into anti-inflammatory macrophages that secrete interleukin-10 and inhi ...[more]