Dataset Information

Extracellular vesicles are crucial mediators in orchestrating brain development and disease

ABSTRACT: Extracellular vesicles have been the center of many studies focusing on neuron-to-neuron communication while the role of EVs in progenitor-to-neuron and -astrocyte communication occurring during brain development has not been systematically investigated. In this project, we focus on the physiological characterization, dynamic and function of human EVs during human brain development using human-derived cerebral organoids, neural progenitors, neurons and astrocytes. We examined the composition and function of EVs, in patients with myoclonic epilepsy and find alterations in size, composition and function. This study sheds new light on the biology of EVs during brain development.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebral Cortex Neuron, Astrocyte Of The Cerebral Cortex, Cell Culture, Neural Progenitor Cell

DISEASE(S): Progressive Myoclonus Epilepsy 1a

SUBMITTER: Giuseppina Maccarrone

LAB HEAD: Silvia Cappello

PROVIDER: PXD028438 | Pride | 2023-07-20

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20210427_TTOF01_LC12_19_SA_Orbi3840_Sample01_2_B2_1_4101.d.zip	Other
	20210427_TTOF01_LC12_19_SA_Orbi3840_Sample01_3_B1_1_4142.d.zip	Other
	20210427_TTOF01_LC12_19_SA_Orbi3840_Sample01_F1_1_4058.d.zip	Other
	20210427_TTOF01_LC12_19_SA_Orbi3840_Sample03_2_B3_1_4102.d.zip	Other
	20210427_TTOF01_LC12_19_SA_Orbi3840_Sample03_3_B2_1_4143.d.zip	Other

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Publications

Non-cell-autonomous regulation of interneuron specification mediated by extracellular vesicles.

Pipicelli Fabrizia F Baumann Natalia N Di Giaimo Rossella R Forero-Echeverry Andrea A Kyrousi Christina C Bonrath Rebecca R Maccarrone Giuseppina G Jabaudon Denis D Cappello Silvia S

Science advances 20230519 20

Disruption in neurogenesis and neuronal migration can influence the assembly of cortical circuits, affecting the excitatory-inhibitory balance and resulting in neurodevelopmental and neuropsychiatric disorders. Using ventral cerebral organoids and dorsoventral cerebral assembloids with mutations in the extracellular matrix gene <i>LGALS3BP</i>, we show that extracellular vesicles released into the extracellular environment regulate the molecular differentiation of neurons, resulting in alteratio ...[more]

PMID: 37205765

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