Proteomics

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Guillain-Barré syndrome following Zika virus infection is associated with a diverse spectrum of peripheral nerve reactive antibodies

ABSTRACT: Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurological side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed in 1:4000 ZIKV cases. Whether the neurological symptoms of ZIKV infection are a consequence of autoimmunity or direct neurotoxicity is unclear.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human) Rattus Rattus (black Rat)

TISSUE(S): Cell Culture, Blood Serum, Electrically Active Cell

DISEASE(S): Neuroblastoma

SUBMITTER: Georgina Berridge  

LAB HEAD: Roman Fischer

PROVIDER: PXD028476 | Pride | 2023-03-10

REPOSITORIES: pride

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FL1122_MSQ1685_20190328_SRinaldi_008-Elution_run.mgf Mgf
FL1122_MSQ1685_20190328_SRinaldi_008-Elution_run.mzxml Mzxml
FL1122_MSQ1685_20190328_SRinaldi_008-Elution_run.raw Raw
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<h4>Background and objectives</h4>Recent outbreaks of Zika virus (ZIKV) in South and Central America have highlighted significant neurologic side effects. Concurrence with the inflammatory neuropathy Guillain-Barré syndrome (GBS) is observed in 1:4,000 ZIKV cases. Whether the neurologic symptoms of ZIKV infection are immune mediated is unclear. We used rodent and human live cellular models to screen for anti-peripheral nerve reactive IgG and IgM autoantibodies in the sera of patients with ZIKV w  ...[more]

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