Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): T Cell
SUBMITTER: Hossein Fazelinia
LAB HEAD: Paula M. Oliver, PhD
PROVIDER: PXD028492 | Pride | 2022-06-09
REPOSITORIES: Pride
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PO1473_MQ1610txt.zip | Other | |||
PO1480_MQ1610txt.zip | Other | |||
checksum.txt | Txt | |||
q200611_PO1473_C1SH.raw | Raw | |||
q200611_PO1473_Cul5.raw | Raw |
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Nature communications 20220519 1
Antigen encounter directs CD4<sup>+</sup> T cells to differentiate into T helper or regulatory cells. This process focuses the immune response on the invading pathogen and limits tissue damage. Mechanisms that govern T helper cell versus T regulatory cell fate remain poorly understood. Here, we show that the E3 ubiquitin ligase Cul5 determines fate selection in CD4<sup>+</sup> T cells by regulating IL-4 receptor signaling. Mice lacking Cul5 in T cells develop Th2 and Th9 inflammation and show pa ...[more]