Dataset Information

PGRMC1 promotes progestin-dependent proliferation of breast cancer cells by binding prohibitins resulting in activation of ERα signaling

ABSTRACT: Combined menopausal hormone therapy is associated with increased breast cancer risk in postmenopausal women. In our previous studies, progesterone receptor membrane component 1 (PGRMC1) was shown to play a role in progestins’ mode of action, resulting in enhanced proliferation of breast cancer cells. Here we describe a potential mechanism by which PGRMC1 contributes to breast cancer progression via interaction with prohibitins, inhibiting their function as transcription factor repressors, thereby facilitating estrogen receptor alpha (ERα) transcriptional activity and enhancing oncogenic signaling upon treatment with certain progestins, such as norethisterone and dydrogesterone.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Gereon Poschmann

LAB HEAD: Gereon Poschmann

PROVIDER: PXD028537 | Pride | 2022-02-16

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

Items per page:

1 - 5 of 22

Publications

PGRMC1 Promotes Progestin-Dependent Proliferation of Breast Cancer Cells by Binding Prohibitins Resulting in Activation of ERα Signaling.

Bai Yingxue Y Ludescher Marina M Poschmann Gereon G Stühler Kai K Wyrich Martine M Oles Julia J Franken André A Rivandi Mahdi M Abramova Anna A Reinhardt Florian F Ruckhäberle Eugen E Niederacher Dieter D Fehm Tanja T Cahill Michael A MA Stamm Nadia N Neubauer Hans H

Cancers 20211111 22

In previous studies, we reported that progesterone receptor membrane component 1 (PGRMC1) is implicated in progestin signaling and possibly associated with increased breast cancer risk upon combined hormone replacement therapy. To gain mechanistic insight, we searched for potential PGRMC1 interaction partners upon progestin treatment by co-immunoprecipitation and mass spectrometry. The interactions with the identified partners were further characterized with respect to PGRMC1 phosphorylation sta ...[more]

PMID: 34830790

			Action	DRS
	OE07553.raw	Raw
	OE07554.raw	Raw
	OE07555.raw	Raw
	OE07556.raw	Raw
	OE07557.raw	Raw

Dataset Information

PGRMC1 promotes progestin-dependent proliferation of breast cancer cells by binding prohibitins resulting in activation of ERα signaling

Dataset's files

Publications

PGRMC1 Promotes Progestin-Dependent Proliferation of Breast Cancer Cells by Binding Prohibitins Resulting in Activation of ERα Signaling.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Similar Datasets

Estrogen receptor and mTOR signaling rewires cancer metabolism in obesity-associated breast cancer
2019-05-11 | GSE114372 | GEO

Effects of PGRMC1 phosphorylation on genome integrity and epigenetics
2019-12-01 | E-MTAB-8218 | biostudies-arrayexpress

Estrogen Receptor α (ERα)-mTOR signaling crosstalk rewires cancer cell metabolism providing a mechanism underlying obesity-associated postmenopausal breast cancer [ChIP-seq]
2020-01-11 | GSE93510 | GEO

Estrogen Receptor α (ERα)-mTOR signaling crosstalk rewires cancer cell metabolism providing a mechanism underlying obesity-associated postmenopausal breast cancer [RNA-seq]
2020-01-11 | GSE93505 | GEO

LC-MSMS with isobaric tagging of Pgrmc1 KO mouse liver membranes expressing Flag-Pgrmc1 or Y113F Flag-Pgrmc1
2022-02-16 | PXD028288 | Pride

LC-MSMS with isobaric tagging on Flag-coimmunoprecipitation eluates from Flag-Pgrmc1 and Y113F Flag-Pgrmc1 expressing Pgrmc1 KO mouse liver membranes
2022-02-15 | PXD028284 | Pride

Quantitative analysis of wild-type and Pgrmc1 knockout mouse liver transcriptomes
2021-11-24 | GSE174375 | GEO

Effects of PGRMC1 phosphorylation status on MIA PaCa-2 cells
2020-03-03 | PXD014716 | Pride

PGRMC1 is a novel potential tumor biomarker of human renal cell carcinoma based on quantitative proteomics and integrative biological assessments
2017-01-24 | PXD004595 | Pride

Dynamic changes during adaptation to estrogen deprivation in MCF7 cell line
2010-09-01 | E-GEOD-20361 | biostudies-arrayexpress