Proteomics

Dataset Information

0

Shotgun proteomics on sterile culture supernatant from S. aureus clinical isolates


ABSTRACT: Shotgun proteomics on sterile culture supernatant from S. aureus clinical isolates to determine proteins associated with pro-inflammatory phenotype.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Annika Krueger  

LAB HEAD: Ian Frazer

PROVIDER: PXD028604 | Pride | 2022-02-22

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
A259.index Other
A259.raw Raw
MSdata_Swissprot_MaxQuantOutput_PerseusFilteredTransformedImputed.txt Txt
MSdata_Swissprot_MaxQuantOutput_Raw.txt Txt
SSA_101.index Other
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Publications

Secreted Toxins From <i>Staphylococcus aureus</i> Strains Isolated From Keratinocyte Skin Cancers Mediate Pro-tumorigenic Inflammatory Responses in the Skin.

Krueger Annika A   Zaugg Julian J   Chisholm Sarah S   Linedale Richard R   Lachner Nancy N   Teoh Siok Min SM   Tuong Zewen K ZK   Lukowski Samuel W SW   Morrison Mark M   Soyer H Peter HP   Hugenholtz Philip P   Hill Michelle M MM   Frazer Ian H IH  

Frontiers in microbiology 20220125


Squamous cell carcinoma (SCC) is a common type of skin cancer that typically arises from premalignant precursor lesions named actinic keratoses (AK). Chronic inflammation is a well-known promoter of skin cancer progression. AK and SCC have been associated with an overabundance of the bacterium <i>Staphylococcus aureus</i> (<i>S. aureus</i>). Certain secreted products from <i>S. aureus</i> are known to promote cutaneous pro-inflammatory responses; however, not all <i>S. aureus</i> strains produce  ...[more]

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