Proteomics

Dataset Information

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Ubiquitination regulation of streptococcus agalactiae infection in dairy cow mammary epithelial cells


ABSTRACT: A total of 5239 proteins were identified in this study, of which 4601 proteins contained quantitative information. If 1.5 times is used as the change threshold and t-test p-value<0.05 as the standard, then among the quantified proteins, the expression of 325 proteins in the T/C comparison group will be up-regulated and the expression of 704 proteins will be down-regulated. Based on the above data, we conducted a systematic bioinformatics analysis of proteins containing quantitative information, including protein annotation, functional classification, functional enrichment, and cluster analysis based on functional enrichment. And combining the above information provides a reference direction for the downstream in-depth research based on proteomics.

INSTRUMENT(S): 6220 Time-of-Flight LC/MS

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Xin Li  

LAB HEAD: Jinjin Tong

PROVIDER: PXD028659 | Pride | 2022-10-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
HA153LPUbB1_A1_Slot1-40_1_9951.d.zip Other
HA153LPUbB1_A2_Slot1-41_1_9953.d.zip Other
HA153LPUbB1_A3_Slot1-42_1_9955.d.zip Other
HA153LPUbB1_B1_Slot1-43_1_9957.d.zip Other
HA153LPUbB1_B2_Slot1-44_1_9959.d.zip Other
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Publications

The Analysis of the Ubiquitylomic Responses to <i>Streptococcus agalactiae</i> Infection in Bovine Mammary Gland Epithelial Cells.

Tong Jinjin J   Ji Xintong X   Zhang Hua H   Xiong Benhai B   Cui Defeng D   Jiang Linshu L  

Journal of inflammation research 20220727


<h4>Purpose</h4><i>Streptococcus agalactiae</i> is one of the primary pathogens responsible for subclinical mastitis, a significant economic burden for dairy farms. An essential component of the immune response to infection is ubiquitination, which plays important roles in the complex interactions between the pathogen and host.<h4>Materials and methods</h4>In the present study, quantitative ubiquitylomics was performed to profile changes in the global ubiquitinome of bovine mammary gland epithel  ...[more]

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