Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Escherichia Coli
TISSUE(S): Cell Culture
SUBMITTER: Yanlong Ji
LAB HEAD: Henning Urlaub
PROVIDER: PXD028792 | Pride | 2022-03-20
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
1st_dataset.zip | Other | |||
2nd_dataset.zip | Other | |||
3rd_dataset.zip | Other | |||
4th_dataset.zip | Other | |||
KT_Pan_171117_lysate_ctl_elute_1.raw | Raw |
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Open biology 20220316 3
Cyclin-dependent kinases (CDKs) are key players in cell cycle regulation and transcription. The CDK-family member Cdk10 is important for neural development and can act as a tumour suppressor, but the underlying molecular mechanisms are largely unknown. Here, we provide an in-depth analysis of Cdk10 substrate specificity and function. Using recombinant Cdk10/CycQ protein complexes, we characterize RNA pol II CTD, c-MYC and RB1 as <i>in vitro</i> protein substrates. Using an analogue-sensitive mut ...[more]