Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Erythrocyte, Cell Culture
DISEASE(S): Acute Leukemia
SUBMITTER: Hye Ji Cha
LAB HEAD: Stuart H Orkin
PROVIDER: PXD028867 | Pride | 2021-11-11
REPOSITORIES: Pride
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Cha Hye Ji HJ Uyan Özgün Ö Kai Yan Y Liu Tianxin T Zhu Qian Q Tothova Zuzana Z Botten Giovanni A GA Xu Jian J Yuan Guo-Cheng GC Dekker Job J Orkin Stuart H SH
Nature communications 20211029 1
Precise control of gene expression during differentiation relies on the interplay of chromatin and nuclear structure. Despite an established contribution of nuclear membrane proteins to developmental gene regulation, little is known regarding the role of inner nuclear proteins. Here we demonstrate that loss of the nuclear scaffolding protein Matrin-3 (Matr3) in erythroid cells leads to morphological and gene expression changes characteristic of accelerated maturation, as well as broad alteration ...[more]