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Plasmodium falciparum GBP2 pulldown

ABSTRACT: This experiment was conducted to learn about the potential biological roles of P. falciparum GBP2 (PfGBP2), a protein identified as part of the telomeric proteome in the malaria parasite P. falciparum. HA-tagged GBP2 protein was immunoprecipitated from P. falciparum parasites and its interactome was obtained via mass spectrometry. See preprint https://doi.org/10.1101/2021.07.02.450898

INSTRUMENT(S): Q Exactive

ORGANISM(S): Plasmodium Falciparum (isolate 3d7)

TISSUE(S): Blood Cell

DISEASE(S): Malaria

SUBMITTER: Catherine Merrick

LAB HEAD: Catherine J Merrick

PROVIDER: PXD028903 | Pride | 2022-04-04

REPOSITORIES: Pride

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			Action	DRS
	P834_3D7_GBP2_2.raw.raw	Raw
	P932_3D7_GBP2_1.raw.raw	Raw
	P932_3D7_WT_1.raw.raw	Raw
	allPeptides.txt	Txt
	checksum.txt	Txt

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Publications

Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex DNA and RNA.

Edwards-Smallbone James J Jensen Anders L AL Roberts Lydia E LE Totañes Francis Isidore G FIG Hart Sarah R SR Merrick Catherine J CJ

Frontiers in cellular and infection microbiology 20220222

In the early-diverging protozoan parasite Plasmodium, few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of most eukaryotes, contain guanine-rich repeats that can form G-quadruplex structures. In model systems, quadruplex-binding drugs can disrupt telomere maintenance and some quadruplex-binding drugs are potent anti-plasmodial agents. Therefore, telomere-interacting and quadruplex-interacting proteins may offer new targets f ...[more]

PMID: 35273922

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