Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Macrophage
SUBMITTER: Prerana Wagle
LAB HEAD: Jan Rybniker
PROVIDER: PXD029017 | Pride | 2022-02-17
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
1986.sps | Other | |||
1986_dDIA.sne | Other | |||
1986_dDIA_Report_PC.setup.txt | Txt | |||
1986_dDIA_Report_PC.tsv | Tabular | |||
1986_dDIA_Report_PEP.setup.txt | Txt |
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Theobald Sebastian J SJ Gräb Jessica J Fritsch Melanie M Suárez Isabelle I Eisfeld Hannah S HS Winter Sandra S Koch Maximilian M Hölscher Christoph C Pasparakis Manolis M Kashkar Hamid H Rybniker Jan J
Cell death discovery 20211030 1
Necrotic cell death represents a major pathogenic mechanism of Mycobacterium tuberculosis (Mtb) infection. It is increasingly evident that Mtb induces several types of regulated necrosis but how these are interconnected and linked to the release of pro-inflammatory cytokines remains unknown. Exploiting a clinical cohort of tuberculosis patients, we show here that the number and size of necrotic lesions correlates with IL-1β plasma levels as a strong indicator of inflammasome activation. Our mech ...[more]