Proteomics

Dataset Information

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N1-methylpseudouridine found within COVID-19 mRNA vaccines produces faithful protein products


ABSTRACT: The COVID mRNA vaccines utilize the modified nucleobase N1-methylpseudouridine, in place of canonical uridine, to improve immunogenicity and protein yield. However, relatively few studies have investigated the effect of modified nucleobases on the fidelity of protein translation. Given the interest in the COVID mRNA vaccines, we sought to investigate how N1-methylpseudouridine (and the related modification pseudouridine) is read by ribosomes.

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive

ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2

SUBMITTER: Kyusik Kim  

LAB HEAD: Hani Zaher

PROVIDER: PXD029291 | Pride | 2022-08-18

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20220120_Zaher_2045_OB_01_GFP.raw Raw
20220120_Zaher_2045_OB_02_11.raw Raw
20220120_Zaher_2045_OB_03_12.raw Raw
20220120_Zaher_2045_OB_04_13.raw Raw
20220121_Zaher_2045_OB_05_21.raw Raw
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