Dataset Information

Adipocyte-derived extracellular vesicles promote breast cancer progression in Type 2 diabetes

ABSTRACT: Adipocytes regulate breast cancer aggressiveness through exosomes that encode patient metabolic status.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Subcutaneous Preadipocyte

DISEASE(S): Breast Cancer

SUBMITTER: Naser Jafari

LAB HEAD: Gerald V Denis

PROVIDER: PXD029369 | Pride | 2022-06-09

REPOSITORIES: Pride

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Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes.

Jafari Naser N Kolla Manohar M Meshulam Tova T Shafran Jordan S JS Qiu Yuhan Y Casey Allison N AN Pompa Isabella R IR Ennis Christina S CS Mazzeo Carla S CS Rabhi Nabil N Farmer Stephen R SR Denis Gerald V GV

Science signaling 20211123 710

Obesity and metabolic diseases, such as insulin resistance and type 2 diabetes (T2D), are associated with metastatic breast cancer in postmenopausal women. Here, we investigated the critical cellular and molecular factors behind this link. We found that primary human adipocytes shed extracellular vesicles, specifically exosomes, that induced the expression of genes associated with epithelial-to-mesenchymal transition (EMT) and cancer stem–like cell (CSC) traits in cocultured breast cancer cell l ...[more]

PMID: 34813359

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			Action	DRS
	32804T2D.msf	Msf
	32804T2DF1.raw	Raw
	32804T2DF2.raw	Raw
	32807Normal.msf	Msf
	32807NormalF1.raw	Raw