Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Fibroblast
SUBMITTER: Adhideb Ghosh
LAB HEAD: Prof. Dr. Ori Bar-Nur
PROVIDER: PXD029379 | Pride | 2022-05-19
REPOSITORIES: pride
Items per page: 5 1 - 5 of 27 |
Kim Inseon I Ghosh Adhideb A Bundschuh Nicola N Hinte Laura L Petrosyan Eduard E von Meyenn Ferdinand F Bar-Nur Ori O
Science advances 20220406 14
Transient MyoD overexpression in concert with small molecule treatment reprograms mouse fibroblasts into induced myogenic progenitor cells (iMPCs). However, the molecular landscape and mechanisms orchestrating this cellular conversion remain unknown. Here, we undertook an integrative multiomics approach to delineate the process of iMPC reprogramming in comparison to myogenic transdifferentiation mediated solely by MyoD. Using transcriptomics, proteomics, and genome-wide chromatin accessibility a ...[more]