Dataset Information

Proteome analysis of microvessels from CAA and AD patients

ABSTRACT: Cerebral amyloid angiopathy (CAA) is an age-related condition and a major cause of intracerebral hemorrhage and cognitive decline that shows close links with Alzheimer's disease (AD). CAA is characterized by the aggregation of amyloid-β (Aβ) peptides and formation of Aβ deposits in the brain vasculature resulting in a disruption of the angioarchitecture. Capillaries are a critical site of Aβ pathology in CAA type 1 and become dysfunctional during disease progression. Here, applying an advanced protocol for the isolation of parenchymal microvessels from post-mortem brain tissue combined with liquid chromatography tandem mass spectrometry (LC-MS/MS), we determined the proteomes of CAA type 1 cases (n = 12) including a patient with hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D), and of AD cases without microvascular amyloid pathology (n = 13) in comparison to neurologically healthy controls (n = 12).

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Microvessel

DISEASE(S): Cerebral Amyloid Angiopathy,Alzheimer's Disease

SUBMITTER: Andreas Zellner

LAB HEAD: Bernhard Kuster

PROVIDER: PXD029380 | Pride | 2022-02-16

REPOSITORIES: Pride

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Publications

Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates.

Zellner Andreas A Müller Stephan A SA Lindner Barbara B Beaufort Nathalie N Rozemuller Annemieke J M AJM Arzberger Thomas T Gassen Nils C NC Lichtenthaler Stefan F SF Kuster Bernhard B Haffner Christof C Dichgans Martin M Dichgans Martin M

Acta neuropathologica communications 20220124 1

Cerebral amyloid angiopathy (CAA) is an age-related condition and a major cause of intracerebral hemorrhage and cognitive decline that shows close links with Alzheimer's disease (AD). CAA is characterized by the aggregation of amyloid-β (Aβ) peptides and formation of Aβ deposits in the brain vasculature resulting in a disruption of the angioarchitecture. Capillaries are a critical site of Aβ pathology in CAA type 1 and become dysfunctional during disease progression. Here, applying an advanced p ...[more]

PMID: 35074002

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