Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Retinal Pigment Epithelial Cell, Cell Culture
DISEASE(S): Age Related Macular Degeneration
SUBMITTER: Mohamed Ali Jarboui
LAB HEAD: Angela Armento
PROVIDER: PXD029408 | Pride | 2022-02-16
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
CFH_ctr_Lys_1.raw | Raw | |||
CFH_ctr_Lys_2.raw | Raw | |||
CFH_ctr_Lys_3.raw | Raw | |||
CFH_ctr_Lys_4.raw | Raw | |||
IGG_Lys_1.raw | Raw |
Items per page: 5 1 - 5 of 10 |
Merle David A DA Provenzano Francesca F Jarboui Mohamed Ali MA Kilger Ellen E Clark Simon J SJ Deleidi Michela M Armento Angela A Ueffing Marius M
Antioxidants (Basel, Switzerland) 20211203 12
Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including aging, genetics, and lifestyle choices. The combination of these factors leads to oxidative stress, inflammation, and metabolic failure in the retinal pigment epithelium (RPE) with subsequent degeneration of photoreceptors in the retina. The alternative complement pathway is tightly linked to AMD. In particular, the genetic variant in the complement factor H gene ...[more]