Proteomics

Dataset Information

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Huma Multiple Myeloma Cell line, AMO1, treated with NCP26, LC-MSMS analysis

ABSTRACT: The human multiple myeloma cell line, AMO1, was treated with NCP26, an ATP-competitive EPRS inhibitor, and a total proteome-wide analysis was performed to determine the effect of NCP26 treatment on protein dynamics.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Plasma Cell, Multiple Myeloma Cell Line

DISEASE(S): Multiple Myeloma

SUBMITTER: Keiji Kurata  

LAB HEAD: Kenneth Carl Anderson

PROVIDER: PXD029453 | Pride | 2023-03-11

REPOSITORIES: pride

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Dataset's files

Source:
Action DRS
13886_g07859_tc-s738_F1A_2.mzid.gz Mzid
13887_g07860_tc-s738_F2A_2.mzid.gz Mzid
13888_g07861_tc-s738_F3A_2.mzid.gz Mzid
13889_g07862_tc-s738_F4A_2.mzid.gz Mzid
13890_g07863_tc-s738_F5A_2.mzid.gz Mzid
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Publications

Multiple myeloma (MM) is a plasma cell malignancy characterised by aberrant production of immunoglobulins requiring survival mechanisms to adapt to proteotoxic stress. We here show that glutamyl-prolyl-tRNA synthetase (GluProRS) inhibition constitutes a novel therapeutic target. Genomic data suggest that GluProRS promotes disease progression and is associated with poor prognosis, while downregulation in MM cells triggers apoptosis. We developed NCP26, a novel ATP-competitive ProRS inhibitor that  ...[more]

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