Dataset Information
Secretomics of TGF-B1-stimulated IMR-90 cells with and without sanglifehrin A
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Christina Woo
LAB HEAD: Christina M. Woo
PROVIDER: PXD029541 | Pride | 2024-10-17
REPOSITORIES: pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 210205L_SAM08166_Hope779_fr.mgf | Mgf | |||
| 210205L_SAM08166_Hope779_fr.msf | Msf | |||
| 210205L_SAM08166_Hope779_fr2.raw | Raw | |||
| 210205L_SAM08166_Hope779_fr3.raw | Raw | |||
| 210205L_SAM08166_Hope779_fr4.raw | Raw |
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Publications
Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B.
JCI insight 20240620 15
Pathological deposition and crosslinking of collagen type I by activated myofibroblasts drives progressive tissue fibrosis. Therapies that inhibit collagen synthesis have potential as antifibrotic agents. We identify the collagen chaperone cyclophilin B as a major cellular target of the natural product sanglifehrin A (SfA) using photoaffinity labeling and chemical proteomics. Mechanistically, SfA inhibits and induces the secretion of cyclophilin B from the endoplasmic reticulum (ER) and prevents ...[more]
