Proteomics

Dataset Information

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To identify the nuclear partner(s) of TYRO3 in colon cells using LC-Quadrupole Time-of-Flight Mass Spectrometry.

ABSTRACT: Colorectal cancer (CRC) is one of the most common death-related cancers worldwide. Aberrant expression of oncogenes is regarded as a predominant factor in CRC development. In our study, we found that TYRO3 intracellular domain nuclear translocation promotes CRC cell proliferation, metastasis, and tumor progression. To identify downstream effector that transmits the cellular functions of nuclear TYRO3, we performed nuclear TYRO3 co-immunoprecipitation.

INSTRUMENT(S): impact HD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Colon

SUBMITTER: Pei-Ling Hsu  

LAB HEAD: Shaw-Jenq Tsai

PROVIDER: PXD029743 | Pride | 2023-05-10

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20190130_sample_01_1-F_1_01_4871_4.1.362.7.mgf Mgf
20190130_sample_02_1-F_2_01_4873_4.1.362.7.mgf Mgf
20190130_sample_03_1-F_3_01_4875_4.1.362.7.mgf Mgf
20190130_sample_04_1-F_4_01_4877_4.1.362.7.mgf Mgf
20190130_sample_05_1-F_5_01_4879_4.1.362.7.mgf Mgf
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Publications

Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis.

Hsu Pei-Ling PL   Chien Chun-Wei CW   Tang Yen-An YA   Lin Bo-Wen BW   Lin Shih-Chieh SC   Lin Yi-Syuan YS   Chen Sih-Yu SY   Sun H Sunny HS   Tsai Shaw-Jenq SJ  

Science advances 20230412 15

Metastasis is the main cause of death in many cancers including colorectal cancer (CRC); however, the underlying mechanisms responsible for metastatic progression remain largely unknown. We found that nuclear TYRO3 receptor tyrosine kinase is a strong predictor of poor overall survival in patients with CRC. The metastasis-promoting function of nuclear TYRO3 requires its kinase activity and matrix metalloproteinase-2 (MMP-2)-mediated cleavage but is independent of ligand binding. Using proteomic  ...[more]

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