Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cerebrospinal Fluid
SUBMITTER: Duc Duong
LAB HEAD: Victor Faundez
PROVIDER: PXD029811 | Pride | 2022-10-14
REPOSITORIES: Pride
Zlatic Stephanie A SA Duong Duc D Gadalla Kamal K E KKE Murage Brenda B Ping Lingyan L Shah Ruth R Fink James J JJ Khwaja Omar O Swanson Lindsay C LC Sahin Mustafa M Rayaprolu Sruti S Kumar Prateek P Rangaraju Srikant S Bird Adrian A Tarquinio Daniel D Carpenter Randall R Cobb Stuart S Faundez Victor V
iScience 20220817 9
MECP2 loss-of-function mutations cause Rett syndrome, a neurodevelopmental disorder resulting from a disrupted brain transcriptome. How these transcriptional defects are decoded into a disease proteome remains unknown. We studied the proteome of Rett cerebrospinal fluid (CSF) to identify consensus Rett proteome and ontologies shared across three species. Rett CSF proteomes enriched proteins annotated to HDL lipoproteins, complement, mitochondria, citrate/pyruvate metabolism, synapse compartments ...[more]