Dataset Information
Valvular interstitial cells and mesenchymal stem cell proteomes
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Valve Cell, Aortic Valve
DISEASE(S): Cardiovascular System Disease
SUBMITTER: 
Sasha Singh
LAB HEAD: Elena Aikawa
PROVIDER: PXD029949 | Pride | 2024-01-25
REPOSITORIES: Pride
Dataset's files
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Publications
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.
Cell reports 20220401 2
Cellular heterogeneity of aortic valves complicates the mechanistic evaluation of the calcification processes in calcific aortic valve disease (CAVD), and animal disease models are lacking. In this study, we identify a disease-driver population (DDP) within valvular interstitial cells (VICs). Through stepwise single-cell analysis, phenotype-guided omic profiling, and network-based analysis, we characterize the DDP fingerprint as CD44<sup>high</sup>CD29<sup>+</sup>CD59<sup>+</sup>CD73<sup>+</sup> ...[more]