Proteomics

Dataset Information

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Quantitative label-free proteomic comparison of the omadacycline-induced E. faecium isolates vs initial separation


ABSTRACT: Quantitative label-free proteomic comparison of the omadacycline-induced E. faecium isolates vs initial separation type.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Enterococcus Faecalis (streptococcus Faecalis)

SUBMITTER: Yuxi Zhao  

LAB HEAD: Yuxi Zhao

PROVIDER: PXD029978 | Pride | 2022-02-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20201210-1-2L11-1.mgf Mgf
20201210-1-2L11-1.mzML Mzml
20201210-1-2L11-1.mzid.gz Mzid
20201210-1-2L11-1.raw Raw
20201210-1-2L11-2.raw Raw
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Publications

The Mechanism of Action of Ginkgolic Acid (15:1) against Gram-Positive Bacteria Involves Cross Talk with Iron Homeostasis.

Wen Zewen Z   Zhao Yuxi Y   Gong Zhengyang Z   Tang Yuanyuan Y   Xiong Yanpeng Y   Chen Junwen J   Chen Chengchun C   Zhang Yufang Y   Liu Shanghong S   Zheng Jinxin J   Li Duoyun D   Deng Qiwen Q   Yu Zhijian Z  

Microbiology spectrum 20220112 1


With the increasing reports of community-acquired and nosocomial infection caused by multidrug-resistant Gram-positive pathogens, there is an urgent need to develop new antimicrobial agents with novel antibacterial mechanisms. Here, we investigated the antibacterial activity of the natural product ginkgolic acid (GA) (15:1), derived from Ginkgo biloba, and its potential mode of action against the Gram-positive bacteria Enterococcus faecalis and Staphylococcus aureus. The MIC values of GA (15:1)  ...[more]

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