Proteomics

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Mesenteric fibrosis in small intestinal neuroendocrine tumors.

ABSTRACT: Assessment of mesenteric fibrosis (MF) presence and severity in small-intestinal neuroendocrine tumors (SI-NETs) remains a diagnostic challenge. To explore possible biomarkers for MF presence, a proteomic analysis was performed of the tumor and stroma compartment of primary SI-NETs and paired mesenteric metastasis.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Neuroendocrine Tumor Cell, Stroma, Small Intestine Glandular Cell

DISEASE(S): Small Intestine Neuroendocrine Neoplasm

SUBMITTER: Christoph Stingl  

LAB HEAD: Theo Luider

PROVIDER: PXD029979 | Pride | 2022-05-20

REPOSITORIES: Pride

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Aberrant tryptophan metabolism in stromal cells is associated with mesenteric fibrosis in small intestinal neuroendocrine tumors.

Blažević Anela A   Iyer Anand M AM   van Velthuysen Marie-Louise F MF   Hofland Johannes J   van Koestveld Peter M PM   Franssen Gaston J H GJH   Feelders Richard A RA   Zajec Marina M   Luider Theo M TM   de Herder Wouter W WW   Hofland Leo J LJ  

Endocrine connections 20220429 4

<h4>Background</h4>Increased levels of serotonin secretion are associated with mesenteric fibrosis (MF) in small intestinal neuroendocrine tumors (SI-NETs). However, the profibrotic potential of serotonin differs between patients, and in this study, we aimed to gain an understanding of the mechanisms underlying this variability. To this end, we analyzed the proteins involved in tryptophan metabolism in SI-NETs.<h4>Methods</h4>Proteomes of tumor and stroma from primary SI-NETs and paired mesenter  ...[more]

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