Proteomics

Dataset Information

0

Phosphoproteomcs of the folliculin negative cancer cell line UOK257 +/- lentiviral rescue construct


ABSTRACT: In Birt-Hogg-Dubé (BHD) syndrome, germline mutations in the Folliculin (FLCN) gene lead to an increased risk of renal cancer. To address if FLCN is involved regulating cellular signaling pathways via protein and receptor phosphorylation we determined comprehensive phosphoproteomic profiles of FLCN-POS and FLCN-NEG human tumor cells (UOK257). UOK257 misses the folliculin (FLCN) gene, whereas UOK 257-2 harbours a lentiviral rescue of the FLCN gene. Experiment performed in duplicate. This data set is linked to PXD021346 that describes phosphoproteomics results for human renal tubular epithelial cells (RPTEC/TERT1).

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Renal Carcinoma

SUBMITTER: Sander Piersma  

LAB HEAD: Connie Jimenez

PROVIDER: PXD030237 | Pride | 2022-07-11

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MaxQuant_txt_IMAC.zip Other
MaxQuant_txt_Lysate.zip Other
MaxQuant_txt_pTyr.zip Other
Peptides_lysate.xlsx Xlsx
Phosphopeptides_IMAC.xlsx Xlsx
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