Dataset Information

The Mitochondrial RNA Granule is Necessary for Parkinsonism-Associated Metal Toxicity

ABSTRACT: We measured the proteome of wild type HAP1 cells and cells mutant for the manganese transporter SLC30A10, PARK2, and the ADP-ATP mitochondrial translocator SLC25A4.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Parkinson's Disease

SUBMITTER: Victor Faundez

LAB HEAD: Victor Faundez

PROVIDER: PXD030502 | Pride | 2023-03-11

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Experiment Emory 7146_A from MSB7146AsRP2Pool_01 +11 others.mzid.gz	Mzid
	Experiment Emory 7146_A from MSB7146AsRP2Pool_01 +11 others.mzid_Experiment_Emory_7146_A_from_MSB7146AsRP2Pool_01_+11_others.MGF	Mzid
	Experiment Emory 7146_B from MSB7146BsRP2Pool_01 +11 others.mzid.gz	Mzid
	Experiment Emory 7146_B from MSB7146BsRP2Pool_01 +11 others.mzid_Experiment_Emory_7146_B_from_MSB7146BsRP2Pool_01_+11_others.MGF	Mzid
	MSB7146AsRP2Pool_01.raw	Raw

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Publications

The mitochondrial RNA granule modulates manganese-dependent cell toxicity.

Werner E E Gokhale A A Ackert M M Xu C C Wen Z Z Roberts A M AM Roberts B R BR Vrailas-Mortimer A A Crocker A A Faundez V V

Molecular biology of the cell 20220803 12

Prolonged manganese exposure causes manganism, a neurodegenerative movement disorder. The identity of adaptive and nonadaptive cellular processes targeted by manganese remains mostly unexplored. Here we study mechanisms engaged by manganese in genetic cellular models known to increase susceptibility to manganese exposure, the plasma membrane manganese efflux transporter SLC30A10 and the mitochondrial Parkinson's gene PARK2. We found that SLC30A10 and PARK2 mutations as well as manganese exposure ...[more]

PMID: 35921164

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