Proteomics

Dataset Information

0

The Mitochondrial RNA Granule is Necessary for Parkinsonism-Associated Metal Toxicity


ABSTRACT: We measured the proteome of wild type HAP1 cells and cells mutant for the manganese transporter SLC30A10, PARK2, and the ADP-ATP mitochondrial translocator SLC25A4.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Parkinson's Disease

SUBMITTER: Victor Faundez  

LAB HEAD: Victor Faundez

PROVIDER: PXD030502 | Pride | 2023-03-11

REPOSITORIES: Pride

altmetric image

Publications

The mitochondrial RNA granule modulates manganese-dependent cell toxicity.

Werner E E   Gokhale A A   Ackert M M   Xu C C   Wen Z Z   Roberts A M AM   Roberts B R BR   Vrailas-Mortimer A A   Crocker A A   Faundez V V  

Molecular biology of the cell 20220803 12


Prolonged manganese exposure causes manganism, a neurodegenerative movement disorder. The identity of adaptive and nonadaptive cellular processes targeted by manganese remains mostly unexplored. Here we study mechanisms engaged by manganese in genetic cellular models known to increase susceptibility to manganese exposure, the plasma membrane manganese efflux transporter SLC30A10 and the mitochondrial Parkinson's gene PARK2. We found that SLC30A10 and PARK2 mutations as well as manganese exposure  ...[more]

Similar Datasets

2022-11-09 | GSE192392 | GEO
| PRJNA791334 | ENA
2017-11-01 | GSE88906 | GEO
2013-06-29 | E-GEOD-48416 | biostudies-arrayexpress
2010-06-22 | E-GEOD-18638 | biostudies-arrayexpress
2014-04-11 | E-GEOD-50864 | biostudies-arrayexpress
2011-08-24 | E-GEOD-30932 | biostudies-arrayexpress
2017-06-30 | GSE99332 | GEO
2009-10-21 | GSE18638 | GEO
| S-EPMC9100327 | biostudies-literature