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TMT Screening of Human Samples:SiHa cell

ABSTRACT: A screen for APOA1 downstream proteins affecting platinum-based chemoresistance using Tandem Mass Tag revealed 64 differentially expressed proteins in SiHa cells, which were subjected to Gene Ontology (annotation, Kyoto Encyclopedia of Genes and Genomes enrichment, subcellular localization, structural domain annotation and enrichment, clustering, and interaction network analyses

INSTRUMENT(S): LTQ Orbitrap Elite, Q Exactive

ORGANISM(S): Cancer

TISSUE(S): Cervical Squamo-columnar Junction

DISEASE(S): Cervical Cancer

SUBMITTER: Yue He

LAB HEAD: Yue-Mei Wu

PROVIDER: PXD030885 | Pride | 2022-05-20

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Peptide_identification_files.xml	Xml
	Protein_identification_files.xml	Xml
	Set_of_10_files.msf	Msf
	checksum.txt	Txt

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Publications

Role of APOA1 in the resistance to platinum-based chemotherapy in squamous cervical cancer.

He Yue Y Han Su-Bin SB Liu Yang Y Zhang Jing-Jing JJ Wu Yu-Mei YM

BMC cancer 20220414 1

<h4>Background</h4>To investigate the mechanism by which apolipoprotein A1 (APOA1) enhances the resistance of cervical squamous carcinoma to platinum-based chemotherapy.<h4>Methods</h4>Two cervical squamous carcinoma cell lines (SiHa and Caski) overexpressing APOA1 were constructed, treated with carboplatin, and compared to normal control cells.<h4>Results</h4>In both SiHa and Caski cell lines, the clone-forming ability of CBP-treated cells was lower than that of untreated cells, and the change ...[more]

PMID: 35421932

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