Proteomics

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Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis -- Discovery

ABSTRACT: The pathogenesis of multiple sclerosis (MS) remains to be elucidated. Pediatric-onset MS (POMS) represents the earliest stage of the disease. CSF proteins in POMS may therefore provide causal information. Therefore, the aim of the current study was to analyze CSF proteins in children with an initial CNS acquired demyelinating syndrome (ADS) and to make a comparison between POMS and monophasic ADS (mADS). Patients were selected from two prospective pediatric ADS studies. Liquid chromatography-mass spectrometry was performed in a Dutch discovery cohort (POMS n=28; mADS n=39). Parallel reaction monitoring-mass spectrometry was performed on selected proteins more abundant in POMS with ≥ 8 unique peptides in a combined Dutch and Canadian validation cohort (POMS n=48; mADS n=106).

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebrospinal Fluid

DISEASE(S): Multiple Sclerosis,Pediatric Onset

SUBMITTER: Christoph Stingl  

LAB HEAD: Theo M. Luider

PROVIDER: PXD031004 | Pride | 2022-09-30

REPOSITORIES: Pride

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161204OFc1_MS-1275-DMS010126_180.raw Raw
161204OFc1_MS-1275-DMS010126_180__F125565_.mzid.gz Mzid
161204OFc1_MS-1275-DMS010126_180__F125565_.mzid_161204OFc1_MS-1275-DMS010126_180__F125565_.MGF Mzid
161204OFc1_MS-1275-k0004_190.raw Raw
161204OFc1_MS-1275-k0004_190__F125596_.mzid.gz Mzid
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Neurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis and not monophasic demyelinating syndromes in childhood.

Bruijstens Arlette L AL   Stingl Christoph C   Güzel Coşkun C   Stoop Marcel P MP   Wong Yu Yi M YYM   van Pelt E Daniëlle ED   Banwell Brenda L BL   Bar-Or Amit A   Luider Theo M TM   Neuteboom Rinze F RF  

Multiple sclerosis (Houndmills, Basingstoke, England) 20220924 1

<h4>Background</h4>Pediatric-onset multiple sclerosis (POMS) represents the earliest stage of disease pathogenesis. Investigating the cerebrospinal fluid (CSF) proteome in POMS may provide novel insights into early MS processes.<h4>Objective</h4>To analyze CSF obtained from children at time of initial central nervous system (CNS) acquired demyelinating syndrome (ADS), to compare CSF proteome of those subsequently ascertained as having POMS versus monophasic acquired demyelinating syndrome (mADS)  ...[more]

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