Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver
SUBMITTER: Meital Kupervaser
LAB HEAD: Anthony H. Futerman
PROVIDER: PXD031088 | Pride | 2022-04-04
REPOSITORIES: Pride
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Kim Jiyoon L JL Mestre Beatriz B Malitsky Sergey S Itkin Maxim M Kupervaser Meital M Futerman Anthony H AH
The Journal of biological chemistry 20220216 4
Dihydroceramide is a lipid molecule generated via the action of (dihydro)ceramide synthases (CerSs), which use two substrates, namely sphinganine and fatty acyl-CoAs. Sphinganine is generated via the sequential activity of two integral membrane proteins located in the endoplasmic reticulum. Less is known about the source of the fatty acyl-CoAs, although a number of cytosolic proteins in the pathways of acyl-CoA generation modulate ceramide synthesis via direct or indirect interaction with the Ce ...[more]