Dataset Information

Phosphoproteome profile of Human Brain Hemisphere

ABSTRACT: This project is a continuation of our previous study which resembles Interregional and Inter-hemisphere Proteome of the Human Brain. The current study aims to generate a multiregional phosphoproteome map of 12 neuroanatomical regions from both the hemisphere. The analysis of the raw data was done using MaxQuant and Perseus software. In addition to this phosphopeptides showing equal to and more than 0.75 localization probability and intensities inall the replicates were selected for further analysis. The hemisphere and region specificphosphoproteome expression has also been studied further to understand the functional aspect using in-silico tools. Finally, the data has also been integrated with the previously published proteomic expression in the brainprot (http://www.brainprot.org/) to drive the scientific community in neurobiology research.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Deeptarup Biswas

LAB HEAD: Sanjeeva Srivastava

PROVIDER: PXD031188 | Pride | 2023-03-11

REPOSITORIES: Pride

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Publications

Deep Phosphoproteome Landscape of Interhemispheric Functionality of Neuroanatomical Regions of the Human Brain.

Biswas Deeptarup D Kumari Neha N Lachén-Montes Mercedes M Dutta Sampurna S Agrawal Ishita I Samanta Debabrata D Shenoy Sanjyot Vinayak SV Halder Ankit A Fernández-Irigoyen Joaquín J Padhye Advait Rahul AR Santamaría Enrique E Srivastava Sanjeeva S

Journal of proteome research 20221101 4

Post-translational modifications (PTMs) are one of the compulsive and predominant biological processes that regulate the diverse molecular mechanism, modulate the onset of disease, and are the reason behind the functional diversity of proteins. Despite the widespread research findings in neuroproteomics, one of the key drawbacks has been the lack of proteome-level knowledge of hemispheric lateralization. We have investigated the proteome level expression in different neuroanatomical regions unde ...[more]

PMID: 36317652

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			Action	DRS
	Amygdala_L1.raw	Raw
	Amygdala_L2.raw	Raw
	Amygdala_R1.raw	Raw
	Amygdala_R2.raw	Raw
	BrainStem_L1.raw	Raw