Proteomics

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PLATELET PROTEOME REVEALS FEATURES OF CELL DEATH, ANTIVIRAL RESPONSE AND VIRAL REPLICATION IN COVID-19.

ABSTRACT: This article provides the first proteomic analysis of platelets from COVID-19 patients. Our dataset shows that platelets are reprogrammed during severe COVID-19 and respond with the activation of type I interferon and cell death pathways, indicating platelet participation in the antiviral response. Additionally, identification of proteins involved in translation, mainly in non-surviving, and complete sequencing of SARS-CoV-2 genome call attention to platelets as viral repositories and markers poor prognosis in COVID-19.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet

SUBMITTER: Monique Trugilho  

LAB HEAD: Monique Ramos Oliveira Trugilho

PROVIDER: PXD031251 | Pride | 2022-08-12

REPOSITORIES: Pride

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20200819_13_PlaqCOV05_01b.raw Raw
20200819_13_PlaqCOV05_01b.sqt Other
20200819_13_PlaqCOV05_02b.raw Raw
20200819_13_PlaqCOV05_02b.sqt Other
20200819_13_PlaqCOV05_03b.raw Raw
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Coronavirus disease 2019 (COVID-19) has affected over 400 million people worldwide, leading to 6 million deaths. Among the complex symptomatology of COVID-19, hypercoagulation and thrombosis have been described to directly contribute to lethality, pointing out platelets as an important SARS-CoV-2 target. In this work, we explored the platelet proteome of COVID-19 patients through a label-free shotgun proteomics approach to identify platelet responses to infection, as well as validation experimen  ...[more]

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