Dataset Information
NanoTACs: NanoLuc-Targeting Protein Degraders that Parallel Existing Technology
Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro 2
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Simon Cobbold
LAB HEAD: Simon Cobbold
PROVIDER: PXD031371 | Pride | 2022-05-20
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| PROTAC_10_1_1_4823.d.zip | Other | |||
| PROTAC_1_1_1_4830.d.zip | Other | |||
| PROTAC_2_1_1_4821.d.zip | Other | |||
| PROTAC_3_1_1_4824.d.zip | Other | |||
| PROTAC_4_1_1_4810.d.zip | Other |
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Publications
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.
Nature communications 20220419 1
Modulation of protein abundance using tag-Targeted Protein Degrader (tTPD) systems targeting FKBP12<sup>F36V</sup> (dTAGs) or HaloTag7 (HaloPROTACs) are powerful approaches for preclinical target validation. Interchanging tags and tag-targeting degraders is important to achieve efficient substrate degradation, yet limited degrader/tag pairs are available and side-by-side comparisons have not been performed. To expand the tTPD repertoire we developed catalytic NanoLuc-targeting PROTACs (NanoTACs) ...[more]
