Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: Dawei Dong
LAB HEAD: Dawei W Dong
PROVIDER: PXD031462 | Pride | 2023-03-11
REPOSITORIES: Pride
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KashinaA-19-G120-Sample1-QEP.raw | Raw | |||
KashinaA-19-G120-Sample10-QEP.raw | Raw | |||
KashinaA-19-G120-Sample11-QEP.raw | Raw | |||
KashinaA-19-G120-Sample12-QEP.raw | Raw | |||
KashinaA-19-G120-Sample13-QEP.raw | Raw |
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iScience 20220923 10
Cytoplasmic beta- and gamma-actin are ubiquitously expressed in every eukaryotic cell. They are encoded by different genes, but their amino acid sequences differ only by four conservative substitutions at the N-termini, making it difficult to dissect their individual regulation. Here, we analyzed actin from cultured cells and tissues by mass spectrometry and found that beta, unlike gamma actin, undergoes sequential removal of N-terminal Asp residues, leading to truncated actin species found in b ...[more]