Proteomics

Dataset Information

0

Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses

ABSTRACT: The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome and phosphoproteome. We showed the ebb and flow of several host responses in the lung across viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Xiao Xiao Tang  

LAB HEAD: Xiao Xiao Tang

PROVIDER: PXD031574 | Pride | 2022-04-01

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
KA345TPSTB1_1_1.raw Raw
KA345TPSTB1_1_2.raw Raw
KA345TPSTB1_1_3.raw Raw
KA345TPSTB1_1_4.raw Raw
KA345TPSTB1_2_1.raw Raw
Items per page:
1 - 5 of 61
altmetric image

Publications

Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses.

Wang Zhao Ni ZN   Yang Xiang Sheng XS   Sun Jing J   Zhao Jin Cun JC   Zhong Nan Shan NS   Tang Xiao Xiao XX  

iScience 20220222 3

The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome, and phosphoproteome. We showed the ebb and flow of several host responses in the lung across the viral infect  ...[more]

Similar Datasets

Proteomics Tomato fruit ripening Phosphoproteome
2022-02-17 | PXD027844 | Pride
Transcriptomics Absence of host innate immune responses in SARS-CoV-infected ferrets upon subsequent challenge
2013-05-28 | E-GEOD-11704 | biostudies-arrayexpress
Proteomics Global Phosphoproteomics Reveals Molecular Networks in Systemic Lupus Erythematosus
2023-03-11 | PXD025399 | Pride
Proteomics Global Phosphoproteomics Reveals Molecular Networks in Systemic Lupus Erythematosus
2023-03-11 | PXD025559 | Pride
Proteomics Global Phosphoproteomics Reveals Molecular Networks in Systemic Lupus Erythematosus
2023-03-11 | PXD025076 | Pride
Proteomics Phosphoproteome of SHVV-infection CCO cell
2024-01-26 | PXD041500 | Pride
Proteomics 4D-FastDIA quantitative phosphorylation modification omics analysis before and after expression of Salmonella effector SteC in RAW264.7 cell
2024-02-22 | PXD042038 | Pride
Proteomics Comparative Phenotypic, Proteomic, and Phosphoproteomic Analysis Reveals Different Roles of Serine/Threonine Phosphatase and Kinase in the Growth, Cell Division, and Pathogenicity of Streptococcus suis
2021-11-30 | PXD029994 | Pride
Clinical Main Postoperative Complications After COVID-19
| 5792 | ecrin-mdr-crc
Clinical A Retrospective Cohort Study for Main Postoperative Complications After SARS-CoV-2 Infection
| 12454 | ecrin-mdr-crc