Dataset Information

PPP2R1A is a component of WAVE complex and it is important for cancer cell migration

ABSTRACT: WAVE protein complex is involved in cancer cell motility and migration. We performed a proteomic analysis of WAVE complex components after different migration stimulation and inhibitions.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Breast Cancer

SUBMITTER: Giovanni Chiappetta

LAB HEAD: Joelle Vinh

PROVIDER: PXD031584 | Pride | 2023-07-20

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	HF170414_0482_c_gch_170418202735.raw	Raw
	HF170414_0483_c_gch.raw	Raw
	HF170414_0484_c_gch.raw	Raw
	HF170414_0485_c_gch.raw	Raw
	HF170414_0486_c_gch.raw	Raw

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Publications

PPP2R1A regulates migration persistence through the NHSL1-containing WAVE Shell Complex.

Wang Yanan Y Chiappetta Giovanni G Guérois Raphaël R Liu Yijun Y Romero Stéphane S Boesch Daniel J DJ Krause Matthias M Dessalles Claire A CA Babataheri Avin A Barakat Abdul I AI Chen Baoyu B Vinh Joelle J Polesskaya Anna A Gautreau Alexis M AM

Nature communications 20230615 1

The RAC1-WAVE-Arp2/3 signaling pathway generates branched actin networks that power lamellipodium protrusion of migrating cells. Feedback is thought to control protrusion lifetime and migration persistence, but its molecular circuitry remains elusive. Here, we identify PPP2R1A by proteomics as a protein differentially associated with the WAVE complex subunit ABI1 when RAC1 is activated and downstream generation of branched actin is blocked. PPP2R1A is found to associate at the lamellipodial edge ...[more]

PMID: 37322026

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