Proteomics

Dataset Information

0

Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice


ABSTRACT: Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies have prompted a search for novel therapeutic options. Here we show that treatment of pre-diabetic mice with mitochondrially targeted tamoxifen, a potential anti-cancer agent with senolytic activity, improves glucose tolerance and reduces body weight with most pronounced reduction of visceral adipose tissue due to reduced food intake, suppressed adipogenesis and elimination of senescent cells. Glucose-lowering effect of mitochondrially targeted tamoxifen is linked to improvement of type 2 diabetes mellitus-related hormones profile and is accompanied by reduced lipid accumulation in liver. Lower senescent cell burden in various tissues, as well as its inhibitory effect on pre-adipocyte differentiation, results in lower level of circulating inflammatory mediators that typically enhance metabolic dysfunction. Targeting senescence with mitochodrially targeted tamoxifen thus represents an approach to the treatment of type 2 diabetes mellitus and its related comorbidities, promising a complex impact on senescence-related pathologies in aging population of patients with type 2 diabetes mellitus with potential translation into the clinic.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Pavel Talacko  

LAB HEAD: Sona Stemberkova Hubackova

PROVIDER: PXD031710 | Pride | 2022-05-20

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
600-10.HCD.ITMS.peak.apl Other
600-10.raw Raw
600-11.HCD.ITMS.peak.apl Other
600-11.raw Raw
600-12.HCD.ITMS.peak.apl Other
Items per page:
1 - 5 of 1762
altmetric image

Publications


Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies has prompted a search for novel therapeutic options. Here we show that treatment of pre-diabetic mice with mitochondrially targeted tamoxifen, a potential anti-cancer agent with senolytic activity, improves glucose tolerance and reduces body weight with most pronounced reduction of visceral adipose tissue due to reduced food intake, suppressed adipogenesis and el  ...[more]

Similar Datasets

2020-10-09 | E-MTAB-9578 | biostudies-arrayexpress
| PRJEB51173 | ENA
2021-09-28 | PXD027318 | Pride
| PRJNA483137 | ENA
2022-11-15 | MTBLS4568 | MetaboLights
2021-06-23 | MSV000087694 | GNPS
2010-12-18 | E-GEOD-26168 | biostudies-arrayexpress
| PRJNA934059 | ENA
2017-02-09 | GSE94649 | GEO
2022-05-05 | E-MTAB-10493 | biostudies-arrayexpress