Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: Florian Stieglitz
LAB HEAD: Andreas Pich
PROVIDER: PXD031726 | Pride | 2022-05-19
REPOSITORIES: Pride
Items per page: 1 - 5 of 257 |
International journal of molecular sciences 20220412 8
A <i>Clostridioides difficile</i> infection (CDI) is the most common nosocomial infection worldwide. The main virulence factors of pathogenic <i>C. difficile</i> are TcdA and TcdB, which inhibit small Rho-GTPases. The inhibition of small Rho-GTPases leads to the so-called cytopathic effect, a reorganization of the actin cytoskeleton, an impairment of the colon epithelium barrier function and inflammation. Additionally, TcdB induces a necrotic cell death termed pyknosis in vitro independently fro ...[more]