Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Liver, Cecum, Peritoneum
DISEASE(S): Wounds And Injuries
SUBMITTER: Safouane Kadri
LAB HEAD: Dr. Yuval Rinkevich
PROVIDER: PXD031766 | Pride | 2022-05-20
REPOSITORIES: Pride
Items per page: 1 - 5 of 37 |
Nature immunology 20220330 4
Internal organs heal injuries with new connective tissue, but the cellular and molecular events of this process remain obscure. By tagging extracellular matrix around the mesothelium lining in mouse peritoneum, liver and cecum, here we show that preexisting matrix was transferred across organs into wounds in various injury models. Using proteomics, genetic lineage-tracing and selective injury in juxtaposed organs, we found that the tissue of origin for the transferred matrix likely dictated the ...[more]