Dataset Information

Regulation of stress signaling by SCD1

ABSTRACT: Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic stress but the mechanisms are diffuse. We found that SCD1 inhibition alters the levels of proteins phosphorylated at tyrosine in fibroblasts. Major regulated proteins were identified following immunoprecipitation using an anti-phospho-tyrosine antibody and subsequent proteomic analysis.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Fibroblast

SUBMITTER: Andreas Koeberle

LAB HEAD: Andreas Koeberle

PROVIDER: PXD031890 | Pride | 2022-03-24

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	181122_band_1_CAY.xml	Xml
	181122_band_1_CAY.zip	Other
	181122_band_1_CAY_isotype_control.xml	Xml
	181122_band_1_CAY_isotype_control.zip	Other
	181122_band_1_w-o.xml	Xml

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Publications

PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling.

Thürmer Maria M Gollowitzer André A Pein Helmut H Neukirch Konstantin K Gelmez Elif E Waltl Lorenz L Wielsch Natalie N Winkler René R Löser Konstantin K Grander Julia J Hotze Madlen M Harder Sönke S Döding Annika A Meßner Martina M Troisi Fabiana F Ardelt Maximilian M Schlüter Hartmut H Pachmayr Johanna J Gutiérrez-Gutiérrez Óscar Ó Rudolph Karl Lenhard KL Thedieck Kathrin K Schulze-Späte Ulrike U González-Estévez Cristina C Kosan Christian C Svatoš Aleš A Kwiatkowski Marcel M Koeberle Andreas A

Nature communications 20220527 1

Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic stress but the mechanisms are diffuse. Here, we show that 1,2-dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol) [PI(18:1/18:1)] is a SCD1-derived signaling lipid, which inhibits p38 mitogen-activated protein kinase activation, count ...[more]

PMID: 35624087

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