Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Kidney
SUBMITTER: francesca grassi scalvini
LAB HEAD: Francesca Grassi Scalvini
PROVIDER: PXD031915 | Pride | 2022-05-20
REPOSITORIES: Pride
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Dozio Elena E Maffioli Elisa E Vianello Elena E Nonnis Simona S Grassi Scalvini Francesca F Spatola Leonardo L Roccabianca Paola P Tedeschi Gabriella G Corsi Romanelli Massimiliano Marco MM
International journal of molecular sciences 20220330 7
The etiopathogenesis of obesity-related chronic kidney disease (CKD) is still scarcely understood. To this aim, we assessed the effect of high-fat diet (HF) on molecular pathways leading to organ damage, steatosis, and fibrosis. Six-week-old male C57BL/6N mice were fed HF diet or normal chow for 20 weeks. Kidneys were collected for genomic, proteomic, histological studies, and lipid quantification. The main findings were as follows: (1) HF diet activated specific pathways leading to fibrosis and ...[more]