Proteomics

Dataset Information

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Cannabinoids modulate proliferation, differentiation, and migration signaling pathways in oligodendrocytes

ABSTRACT: To elucidate the specific molecular signals associated with the activation or blockade of CB1 and CB2 receptors in this glial cell, mass spectrometry-based proteomics and in silico biology tools were used to determine which signaling pathways and molecular mechanisms are triggered in a human oligodendrocytic cell line (MO3.13) by several pharmacological stimuli: the phytocannabinoid cannabidiol (CBD); CB1 and CB2 agonists WIN55,212-2, ACEA, and HU308; CB1 and CB2 antagonists AM251 and AM630; and endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG).

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Oligodendrocyte Precursor Cell, Cell Culture

SUBMITTER: Bradley Smith  

LAB HEAD: Daniel Martins-de-Souza

PROVIDER: PXD031923 | Pride | 2022-06-09

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
ACEA.zip Other
AM251.zip Other
AM630.zip Other
HU.zip Other
MK-ACEA.zip Other
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Publications

Cannabinoids modulate proliferation, differentiation, and migration signaling pathways in oligodendrocytes.

de Almeida Valéria V   Seabra Gabriela G   Reis-de-Oliveira Guilherme G   Zuccoli Giuliana S GS   Rumin Priscila P   Fioramonte Mariana M   Smith Bradley J BJ   Zuardi Antonio W AW   Hallak Jaime E C JEC   Campos Alline C AC   Crippa José A JA   Martins-de-Souza Daniel D  

European archives of psychiatry and clinical neuroscience 20220527 7

Cannabinoid signaling, mainly via CB1 and CB2 receptors, plays an essential role in oligodendrocyte health and functions. However, the specific molecular signals associated with the activation or blockade of CB1 and CB2 receptors in this glial cell have yet to be elucidated. Mass spectrometry-based shotgun proteomics and in silico biology tools were used to determine which signaling pathways and molecular mechanisms are triggered in a human oligodendrocytic cell line (MO3.13) by several pharmaco  ...[more]

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