Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Recombinant Sars Coronavirus
DISEASE(S): Covid-19
SUBMITTER: Zhanru Yu
LAB HEAD: Roman Fischer
PROVIDER: PXD032054 | Pride | 2023-10-24
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
CovidAntigenEpitopeMGF.zip | Other | |||
DB_search_psm.csv | Csv | |||
NP16D103N.zip | Other | |||
NP16D103Y.zip | Other | |||
NP16WT.zip | Other |
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Wellington Dannielle D Yin Zixi Z Yu Zhanru Z Heilig Raphael R Davis Simon S Fischer Roman R Felce Suet Ling SL Antoun Elie E Hublitz Philip P Beveridge Ryan R Dong Danning D Liu Guihai G Yao Xuan X Peng Yanchun Y Kessler Benedikt M BM Dong Tao T
Heliyon 20230914 10
Mutations within viral epitopes can result in escape from T cells, but the contribution of mutations in flanking regions of epitopes in SARS-CoV-2 has not been investigated. Focusing on two SARS-CoV-2 nucleoprotein CD8<sup>+</sup> epitopes, we investigated the contribution of these flanking mutations to proteasomal processing and T cell activation. We found decreased NP<sub>9-17</sub>-B*27:05 CD8<sup>+</sup> T cell responses to the NP-Q7K mutation, likely due to a lack of efficient epitope produ ...[more]